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Index > Protein center > Map3k7(Gene name) > Rat
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  • Map3k7 (Gene name),
  • Mitogen-activated protein kinase kinase kinase 7 (Protein name ),  M3K7_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Map3k7;
    Protein name:
    Mitogen-activated protein kinase kinase kinase 7;
    Alternative:

    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts with TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2. Identified in the TRIKA2 complex composed of MAP3K7, TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2. Interacts with PPM1L. Interaction with PP2A and PPP6C leads to its repressed activity. Interacts with TRAF6 and TAB1/MAP3K7IP1; during IL-1 signaling. Interacts with TAOK1 and TAOK2; interaction with TAOK2 interferes with MAP3K7 interaction with IKKA, thus preventing NF-kappa-B activation. Interacts with WDR34 (via WD domains). Interacts with RBCK1. Interacts with CYLD. Interacts with TGFBR1; induces MAP3K7 activation by TRAF6 (By similarity). Interacts with VRK2 and MAPK8IP1.
    Function:
    Component of a protein kinase signal transduction cascade. Mediator of TRAF6 and TGF-beta signal transduction. Activates IKBKB and MAPK8 in response to TRAF6 signaling. Stimulates NF-kappa-B activation and the p38 MAPK pathway. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK, but not that of NF-kappa-B.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    606
    Sequence:
    50:
    MSTASAASSS | SSSSASEMIE | APSQVLNFEE | IDYKEIEVEE | VVGRGAFGVV | 
    100:
    CKAKWRAKDV | AIKQIESESE | RKAFIVELRQ | LSRVNHPNIV | KLYGACLNPV | 
    150:
    CLVMEYAEGG | SLYNVLHGAE | PLPYYTAAHA | MSWCLQCSQG | VAYLHSMQPK | 
    200:
    ALIHRDLKPP | NLLLVAGGTV | LKICDFGTAC | DIQTHMTNNK | GSAAWMAPEV | 
    250:
    FEGSNYSEKC | DVFSWGIILW | EVITRRKPFD | EIGGPAFRIM | WAVHNGTRPP | 
    300:
    LIKNLPKPIE | SLMTRCWSKD | PSQRPSMEEI | VKIMTHLMRY | FPGADEPLQY | 
    350:
    PCQYSDEGQS | NSATSTGSFM | DIASTNTSNK | SDTNMEQVPA | TNDTIKRLES | 
    400:
    KLLKNQAKQQ | SDSGRLSLGA | SRGSSVESLP | PTSEGKRMSA | DMSEIEARIV | 
    450:
    ATTAYTKPKR | GHRKTASFGN | ILDVPEIVIS | GNGQPRRRSI | QDLTVTGTEP | 
    500:
    GQVSSRSSSP | SVRMITTSGP | TSEKPARSLP | WTPDDSTDTN | GSDNSIPMAY | 
    550:
    LTLDHQLQPL | APCPNSKESM | AVFEQHCKMA | QEYMKVQTEI | ALLLQRKQEL | 
    600:
    VAELDQDEKD | QQNTSRLVQE | HKKLLDENKS | LSTYYQQCKK | QLEVIRSQQQ | 
    606:
    KRQGTS
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Mitogen-activated protein kinase kinase kinase 7
    Cat.:
    E10349b
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    Packing:
    96T
    ELISA Kit for Rat Mitogen-activated protein kinase kinase kinase 7
    Cat.:
    E10349r
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Rat Mitogen-activated protein kinase kinase kinase 7
    Cat.:
    E10349h
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    Packing:
    96T
    ELISA Kit for Rat Mitogen-activated protein kinase kinase kinase 7
    Cat.:
    E10349m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Rat Mitogen-activated protein kinase kinase kinase 7
    Cat.:
    U10349m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Mitogen-activated protein kinase kinase kinase 7
    Cat.:
    U10349r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Mitogen-activated protein kinase kinase kinase 7
    Cat.:
    U10349b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Mitogen-activated protein kinase kinase kinase 7
    Cat.:
    U10349h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Rat Mitogen-activated protein kinase kinase kinase 7
    Cat.:
    P10349Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Mitogen-activated protein kinase kinase kinase 7
    Polyclonal Antibody for Rat Mitogen-activated protein kinase kinase kinase 7
    Cat.:
    P10349Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Mitogen-activated protein kinase kinase kinase 7
    Cat.:
    P10349Rb-h
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat Mitogen-activated protein kinase kinase kinase 7
    Monoclonal Antibody for Rat Mitogen-activated protein kinase kinase kinase 7
    Monoclonal Antibody for Rat Mitogen-activated protein kinase kinase kinase 7
    Monoclonal Antibody for Rat Mitogen-activated protein kinase kinase kinase 7
    Protein for Rat Mitogen-activated protein kinase kinase kinase 7
    Protein for Rat Mitogen-activated protein kinase kinase kinase 7
    Protein for Rat Mitogen-activated protein kinase kinase kinase 7
    Protein for Rat Mitogen-activated protein kinase kinase kinase 7

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    References
    1. 1.
      "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A. , Weinstock G.M. , Metzker M.L. , Muzny D.M. , Sodergren E.J. , Scherer S. , Scott G. , Steffen D. , Worley K.C. , Burch P.E. , Okwuonu G. , Hines S. , Lewis L. , Deramo C. , Delgado O. , Dugan-Rocha S. , Miner G. , Morgan M. , more...
      Nature428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: Brown Norway.
    2. 2.
      "Amgen rat EST program."
      Amgen EST program
      Submitted (2003-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 28-331
      tissue: Hypothalamus.
      tissue: Prostate.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 351-606
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